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Kazuyuki Kuramoto
Kazuyuki Kuramoto
Astellas Pharma
Chemistry
Biochemistry
AMPK
Cell growth
Protein kinase A
4
Papers
6
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Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models.
2021
British Journal of Cancer
Ayako Nakayama
Takeyuki Nagashima
Yoshihiro Nishizono
Kazuyuki Kuramoto
Kenichi Mori
Kazuya Homboh
Masatoshi Yuri
Masashi Shimazaki
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Discovery of 3,5-Dimethylpyridin-4(1H)-one Derivatives as Activators of AMP-Activated Protein Kinase (AMPK)
2020
Chemical & Pharmaceutical Bulletin
Kazuyuki Kuramoto
Yuki Sawada
Naoki Ishibashi
Tomohiro Yamada
Takeyuki Nagashima
Takashi Shin
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Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity.
2020
Chemical & Pharmaceutical Bulletin
Kazuyuki Kuramoto
Yuki Sawada
Tomohiro Yamada
Takeyuki Nagashima
Kei Ohnuki
Takashi Shin
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Development of a Potent and Orally Active Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), ASP4132, as a Clinical Candidate for the Treatment of Human Cancer
2020
Bioorganic & Medicinal Chemistry
Kazuyuki Kuramoto
Hiroyoshi Yamada
Takashi Shin
Yuki Sawada
Hidenori Azami
Tomohiro Yamada
Takeyuki Nagashima
Kei Ohnuki
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