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Mitsuhiko Ikura

University of Toronto
Ontario Institute for Cancer Research
Princess Margaret Cancer Centre

400

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Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine–dependent interface: a model for KRAS oligomerization

2021 Chemical Science
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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.

2021 Nature Communications
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p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis

2021 Journal of Cell Science
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Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.

2021 Journal of Cell Biology
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MO14-2 KRAS Q61H mutation evades the regulation of tyrosyl phosphorylation and renders cancer cells resistant to SHP2 inhibitor

2021 Annals of Oncology
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Regulation of GTPase function by autophosphorylation

2021 bioRxiv
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Lung cancer driven by BRAFG469V mutation is targetable by EGFR kinase inhibitors.

2021 Journal of Thoracic Oncology
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Force-induced changes of α-catenin conformation stabilize vascular junctions independent of vinculin.

2021 Journal of Cell Science
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Two Distinct Structures of Membrane‐associated Homodimers of GTP‐ and GDP‐bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement

2020 Angewandte Chemie
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NMR in integrated biophysical drug discovery for RAS: past, present, and future.

2020 Journal of Biomolecular NMR
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