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Kim Arndt

Cold Spring Harbor Laboratory

25

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Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth.

2015 Oncotarget
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Design and Synthesis of Novel Diaminoquinazolines with in Vivo Efficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway Inhibition

2010 Journal of Medicinal Chemistry
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Synthesis and biological evaluation of tricyclic anilinopyrimidines as IKKβ inhibitors

2010 Bioorganic & Medicinal Chemistry Letters
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The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)

2010 European Journal of Medicinal Chemistry
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Specific IKKβ inhibitor IV blocks streptonigrin-induced NF-κB activity and potentiates its cytotoxic effect on cancer cells

2009 Molecular Carcinogenesis
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Benzo[c][2,7]naphthyridines as inhibitors of PDK-1.

2009 Bioorganic & Medicinal Chemistry Letters
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2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer

2009 Bioorganic & Medicinal Chemistry Letters
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Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.

2008 Journal of Medicinal Chemistry
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IκBα Kinase Inhibitor IKI-1 Conferred Tumor Necrosis Factor α Sensitivity to Pancreatic Cancer Cells and a Xenograft Tumor Model

2008 Cancer Research
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Discovery of Dibenzo[c,f][2,7]naphthyridines as Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 Inhibitors.

2007 Journal of Medicinal Chemistry
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Citations (44)