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Michael Liu
Michael Liu
Vertex Pharmaceuticals
Chemistry
Biochemistry
Hsp90
Molecular biology
Gene isoform
5
Papers
80
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Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.
2015
Bioorganic & Medicinal Chemistry Letters
Timothy Neubert
Mehdi Numa
Justin Ernst
Jeremy Clemens
Paul Krenitsky
Michael Liu
Beth Fleck
Lisa Woody
Harmon Zuccola
Dean Stamos
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Citations (6)
Identification of Novel HSP90α/β Isoform Selective Inhibitors Using Structure-Based Drug Design. Demonstration of Potential Utility in Treating CNS Disorders such as Huntington’s Disease
2014
Journal of Medicinal Chemistry
Justin Ernst
Timothy Neubert
Michael Liu
Samuel Sperry
Harmon Zuccola
Amy Turnbull
Beth Fleck
William Kargo
Lisa Woody
Peggy Chiang
Dao Tran
Weichao Chen
Phillip W. Snyder
Timothy Alcacio
Azin Nezami
James Reynolds
Khisal Ahmed Alvi
Lance Goulet
Dean Stamos
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Citations (42)
Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity—Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases
2014
Bioorganic & Medicinal Chemistry Letters
Justin Ernst
Michael Liu
Harmon Zuccola
Timothy Neubert
Kevin Beaumont
Amy Turnbull
Adam Kallel
Bryan Vought
Dean Stamos
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Citations (32)
Pyrimidines et pyridines utiles comme inhibiteurs des protéines kinases
2009
Greg Henkel
Michael Liu
Timothy Neuberger
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Aminopyrimidines utiles en tant qu'inhibiteurs des protéines kinases
2008
Juan Miguel Jimenez
Andrew Miller
Jeremy Green
Huai Gao
Gregory Henkel
Michael Liu
Timothy Neuberger
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