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Daniel M. Whalen

Wellcome Trust Centre for Human Genetics

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Oxysterols modulate the Hedgehog signalling pathway by binding a novel site on the membrane protein Smoothened, which may offer new options for the treatment of cancers linked to this pathway.

2013
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Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

2013 eLife
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Structural insights into proteoglycan-shaped Hedgehog signaling.

2013 Proceedings of the National Academy of Sciences of the United States of America
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Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

2008 PLOS Pathogens
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