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You-Qun He

Genomics Institute of the Novartis Research Foundation

3

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Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma

2017 Clinical Cancer Research
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A modern in vivo pharmacokinetic paradigm: combining snapshot, rapid and full PK approaches to optimize and expedite early drug discovery

2013 Drug Discovery Today
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Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.

2013 Journal of Medicinal Chemistry
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