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Julia I-Ju Leu

University of Pennsylvania

38

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P53 regulates cellular redox state, ferroptosis and metabolism

2021 Molecular and Cellular Oncology
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HSP70 Inhibition Blocks Adaptive Resistance and Synergizes with MEK Inhibition for the Treatment of NRAS-Mutant MelanomaHSP70 and MEK Inhibition for Melanoma

2021
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A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors.

2020 Cancer Research
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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

2020 bioRxiv
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Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53.

2020 Proceedings of the National Academy of Sciences of the United States of America
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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

2020 eLife
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Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

2019 Proceedings of the National Academy of Sciences of the United States of America
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Tailoring Chemotherapy for the African-Centric S47 Variant of TP53

2018 Cancer Research
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Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function

2017 Oncotarget
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HSP70 inhibition limits FAK-dependent invasion and enhances the response to melanoma treatment with BRAF inhibitors

2016 Cancer Research
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