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Eugene Cruz Amparo
Eugene Cruz Amparo
Wilmington University
Organic chemistry
Thrombin
Biochemistry
Chemistry
Stereochemistry
3
Papers
160
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Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.
2001
Journal of Medicinal Chemistry
Donald Pinto
Michael J. Orwat
Shuaige Wang
John Matthew Fevig
Mimi L. Quan
Eugene Cruz Amparo
Joseph Cacciola
Karen A. Rossi
Richard S. Alexander
Angela Smallwood
Joseph M. Luettgen
Li Liang
Bruce J. Aungst
Matthew Wright
Robert M. Knabb
Pancras C. Wong
Ruth R. Wexler
Patrick Y. S. Lam
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Citations (151)
Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors
1999
Bioorganic & Medicinal Chemistry Letters
Celia Dominguez
Daniel E. Duffy
Qi Han
Richard S. Alexander
Robert A. Galemmo
Jeongsook M. Park
Pancras C. Wong
Eugene Cruz Amparo
Robert M. Knabb
Joseph Luettgen
Ruth R. Wexler
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Citations (9)
Acide boronique et ester inhibiteurs de la thrombine
1994
Eugene Cruz Amparo
William Henry Miller
Gregory James Pacofsky
John Wityak
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1