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Alvin Lu

Boston Children's Hospital
Harvard University

30

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1772

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Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.

2021 ChemBioChem
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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.

2021 Cancer Cell
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Abstract 1021: Investigating the mechanism of PARP7 inhibition in type I interferon signaling by arrayed CRISPR screening

2021
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Abstract 1348: Targeted degradation of PARP14 Using a heterobifunctional small molecule

2021 Cancer Research
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Abstract 48: RBN-2397: A potent and selective small molecule inhibitor of PARP7 that induces tumor-derived antitumor immunity dependent on CD8 T cells

2021 Cancer Research
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A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.

2021 Chemistry & Biology
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Abstract DDT02-01: RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathways

2020 Cancer Research
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Abstract 1038: A potent and selective PARP14 inhibitor decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants

2020 Tumor Biology
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Abstract 506: A bespoke screening platform to study mono(ADP-ribosylation)

2020
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Abstract 3405: PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition leads to tumor regression

2020
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