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Maria B. Goncalves

Wolfson Centre for Age-Related Diseases

18

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871

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Recent Advances in the Design of RAR α and RAR β Agonists as Orally Bioavailable Drugs. A review

2020 Bioorganic & Medicinal Chemistry
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RARβ agonist drug (C286) demonstrates efficacy in a pre-clinical neuropathic pain model restoring multiple pathways via DNA repair mechanisms

2019 iScience
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Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells

2019 The Journal of Neuroscience
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Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury

2019 Bioorganic & Medicinal Chemistry Letters
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Corrigendum to “Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury” [Bioorg. Med. Chem. Lett. 29(8) (2019) 995–1000]

2019 Bioorganic & Medicinal Chemistry Letters
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The regulation of mitochondria dynamics in neurite outgrowth by retinoic acid receptor β signaling

2019 The FASEB Journal
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Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth

2018 Neurobiology of Disease
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Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist

2017 Bioorganic & Medicinal Chemistry
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Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration

2015 The Journal of Neuroscience
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Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist

2013 European Journal of Neuroscience
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