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Manuela M. Brütsch
Manuela M. Brütsch
Scripps Research Institute
Chemistry
Total synthesis
Vinblastine
Organic chemistry
Tubulin binding
5
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83
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Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20′ ethyl substituent
2017
Bioorganic & Medicinal Chemistry Letters
Oliver Allemann
R. Matthew Cross
Manuela M. Brütsch
Aleksandar Radakovic
Dale L. Boger
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Citations (9)
Vinblastine 20′ Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance
2017
Journal of Medicinal Chemistry
John C. Lukesh
Daniel W. Carney
Huijun Dong
R. Matthew Cross
Vyom Shukla
Katharine K. Duncan
Shouliang Yang
Daniel M. Brody
Manuela M. Brütsch
Aleksandar Radakovic
Dale L. Boger
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Citations (14)
Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity
2017
Chemical Science
Shouliang Yang
Kuppusamy Sankar
Colin K. Skepper
Timothy J. Barker
John C. Lukesh
Daniel M. Brody
Manuela M. Brütsch
Dale L. Boger
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Citations (14)
Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface.
2016
Proceedings of the National Academy of Sciences of the United States of America
Daniel W. Carney
John C. Lukesh
Daniel M. Brody
Manuela M. Brütsch
Dale L. Boger
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Citations (18)
Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity
2016
Journal of the American Chemical Society
Oliver Allemann
Manuela M. Brütsch
John C. Lukesh
Daniel M. Brody
Dale L. Boger
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Citations (28)
1