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Mathew P. Leese

University of Bath

47

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N-Phenyl-1,2,3,4-tetrahydroisoquinoline:an alternative scaffold for design of 17β-hydroxysteroid dehydrogenase 1 inhibitors.

2020 ChemMedChem
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Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure

2018 Journal of Medicinal Chemistry
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Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz-Fritsch-Bobbitt reaction with non-activated and moderately-activated systems

2017 Beilstein Journal of Organic Chemistry
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The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression

2015 Anticancer Research
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Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol.

2015 British Journal of Cancer
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Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones

2014 ChemMedChem
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Cover Picture: Tetrahydroisoquinolinone-Based Steroidomimetic and Chimeric Microtubule Disruptors (ChemMedChem 1/2014)

2014 ChemMedChem
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Synthesis, antitubulin, and antiproliferative SAR of C3/C1-substituted tetrahydroisoquinolines.

2014 ChemMedChem
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Tetrahydroisoquinolinone-Based Steroidomimetic and Chimeric Microtubule Disruptors

2014 ChemMedChem
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Optimisation of tetrahydroisoquinoline-based chimeric microtubule disruptors.

2014 ChemMedChem
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Citations (11)