697-P: Exercise Training Remodels Adipocyte-Specific Extracellular Matrix Proteins and Alters Innervation and Vascularization in Inguinal White Adipose Tissue

Recent studies demonstrate that exercise training causes pronounced changes in inguinal white adipose tissue (iWAT). While most of these studies have focused on adaptations related to enhanced lipolysis and beiging of adipocytes, other tissue remodeling processes include innervation and vascularization, and changes in collagen and glycoprotein-rich extracellular matrix (ECM), all critical for adipose tissue function. Here, we determined the effects of exercise training on these iWAT adaptations. Mice were housed in individual cages with (Trained) or without (Sedentary) access to running wheels for 11 days (n=8/group). Exercise training significantly increased: iWAT neuronal innervation assessed by immunolabeling of synaptophysin (2.2 fold; p Disclosure P. Nigro: None. M. Vamvini: None. R. Middelbeek: None. M.F. Hirshman: Stock/Shareholder; Self; Abbott Laboratories, AbbVie Inc., Amgen, Colgate-Palmolive, Eli Lilly and Company, Medtronic. L.J. Goodyear: None.