Factor V Leiden in patients with recurrent fetal loss

S u m m a r y: The factor V Leiden mutation is the most common genetic predisposition to thrombosis. Our purpose was to determine the association of Factor V Leiden mutation (FVL) frequency and recurrent fetal loss.We examined the prevalence of the point mutation in the factor V gene (R 506 Q or Leiden) in 138 unselected women with a history of one or more spontaneous abortion or stillbirth of unexplained etiology. In our referral population women, a statistically significant association of the Leiden mutation with recurrent fetal losses was found. The risk for recurrence of fetal loss tended to be greater in homozygous carriers.