Efficacy of oral ondansetron in acute FPIES: a case series of 6 patients.

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy (1). Acute FPIES is typical and characterized by repetitive and often incoercible emesis starting 1-4 h after ingestion of the culprit food (1). Severe forms may result in dehydration or hypovolemic shock (1). In the absence of biomarkers, the diagnosis of FPIES is based on clinical presentation (1). Symptoms improve after exclusion of the culprit foods and acute FPIES occurs at re-exposure. FPIES generally resolves during the first years of life and an oral food challenge (OFC) is performed to assess tolerance, generally 12-18 months after the last reaction (1).