Optimized Production and Biological Evaluation of 68Ga-PDTMP as a New Agent for PET Bone Scanning

Abstract Introduction In this study, 68 Ga-PDTMP was introduced as a novel agent for PET bone scanning. Methods 68 Ga-PDTMP was prepared with radiochemical purity of higher than 98% at the optimized conditions. Results Stability tests showed no decrease in radiochemical purity, even after 120 min. The capacity binding of 76.3% ± 0.7% after 10 min incubation for 68 Ga-PDTMP was observed. Conclusion Biological studies in normal mice demonstrated that most of the remained activity is transmitted from blood into bones. The results show that 68 Ga-PDTMP can be considered as a potential radiolabelled complex for PET bone scanning.