2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors for the treatment of HCV

Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4-kinase beta (PI4KIIIβ inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIβleads to potent inhibition of HCV replication as observed in genotype (GT) 1a and 1b replicon and GT2a JFH1 virus assays in vitro.