The Role of Remifentanil in Obstetric Analgesia: A Review
2016
Standard for labour analgesia due to its efficacy. In cases of
contraindication, systemic remifentanil is possible as
alternative. The first demonstration of the safety of
remifentanil in obstetric analgesia was in 1996 and since then,
its safety for mother and newborn has been repeatedly
confirmed. The aim of this review is to provide a summary of
current information on the efficacy and safety of remifentanil
during labour. Methods: Search of the US National Library of
Medicine, National Institutes of Health (www.pubmed.gov),
SCOPUS database (www.scopus.com) and Web of Science database
(www.webofknowledge.com) using the key words “labour” and
“remifentanil.” Results: Forty four identified articles were
included into review. We described possible modes of
application, dosage and side-effects for mother, fetus or
newborn in the review. Conclusion: Administration of
remifentanil is appropriate, effective, and with respects to
the mentioned safety principles also a safe alternative to
epidural analgesia in labour. It is highly satisfactory and
comparable to epidural analgesia for parturients despite the
fact that the analgesic efficacy is significantly lower.
Compared to other systemically applied opioids or nitrous
oxide, it is more efficient analgesic and due to its unique
pharmacokinetics also a safer option. To determine the optimal
dosage and mode of administration of remifentanil further
studies are needed.
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