Applying Multiple Pharmacodynamics Index for Evaluation of Extraction Process of Polygonati Rhizoma in Guanxinpin Granule

OBJECTIVE To define the extraction process of Polygonati rhizoma in Guanxinping Granule by multiple pharmacodynamics index.METHOD Myocardial ischemia model of rat was induced by injection of Isoprinosine.Two processes were compared with their effects on...by Isoprinnosine,with one using water extraction(A)and the other using water extraction and alcohol precipitation(B),on electrocardiogram,CK,LDH,MDA and histopathology of myocardial ischemic injury caused by Isoprinosine.RESULT Samples of two processes could decrease the elevated J of ECG,and reduce the level of CK,LDH and MDA.Compared with process B,process A reduced the level of CK,LDH and MDA more obviously(P0.01).Furthermore,no significant improvement was observed on the hyperemia in the samples of process B.CONCLUSION The experiment showed that Polygonati rhizoma in Guanxinping Granule is unfit for alcohol precipitation but for water extraction.