Obezitatea şi cancerul de sân

This paper represents an analysis of the main studies in literature regarding the major molecular mechanisms with respect to the evolution of breast neoplasm in obese patients. Thus, the main molecular mechanisms described in the respective literature are described as follows: the main adipokines (leptin and adiponectin), insulin and insulin-like growth factor receptor, and the estrogen-mediated signaling pathway. There were also analyzed the role of obesity as a prognostic factor and its impact on the main therapeutic modalities applied in the treatment of breast neoplasm, following the data from the current literature. Conclusions. The excess of adipose tissue plays an important role both as a risk factor in the occurrence of breast neoplasm, but also as a prognostic factor in the evolution of breast cancer in this category of patients. Obesity has a negative impact on the application of an optimal treatment sequence in breast neoplasm.