Nanoparticles of lipoic acid esters: preparation and antioxidant effect

Abstract Five lipoic acid esters were synthesized, and their nanoforms based on copolymer Pluronic F68 and phosphatidylcholine were obtained. The most pronounced antioxidant effect on neutrophils activated by phorbol-12-myristate-13-acetate was shown by the nanodispersion containing the derivative of lipoic acid with hexane-1,6-diol, reducing the concentration of reactive oxygen species by 7.5 times.