CASE REPORT "Isaacs Syndrome A Rare Case Report"

Isaac's syndrome also known as neuromyotonia is a rare disorder characterised by spontaneous, continous muscle activity of peripheral nerve origin. The clinical findings seen are muscle twitching, cramps, muscle stiffness, muscle hypertrophy, increased sweating. The main oral cavity related complaint is related to decreased mouth opening. Electromyography shows spontaneous, continuous, irregularly occurring doublet, triplet or multiplet single motor unit discharges, firing at a high intraburst frequency along with fasciculations and fibrillation potentials. Elevated antibody levels against voltage gated potassium channels are also seen in 40% cases. There is no known cure for this syndrome however relief from muscle stiffness and spasms are seen with the administration of anticonvulsants like phenytoin and carbamazepine.