A comparison of adriamycin and mAMSA

Multicellular spheroids were used to compare the two chemotherapeutic agents adriamycin (ADM) and 4′[(9-acridinyl)-amino] methanesulphon-m-anisidide (mAMSA). Chinese hamster cells, V79 379A, a human small cell lung carcinoma, designated ME/MAR, and a human melanoma xenograft, HX117, were grown as spheroids (200 or 400 μm in diameter) and treated with either drug for 1 h, at 37°C, in air. Cytotoxicity was assayed using both cell survival and growth delay.