Randomized Multicenter Trial on Adjuvant Intraportal Chemotherapy for Colorectal Cancer (SAKK 40/81)

The importance and the poor prognosis of colorectal liver metastases are well known. Once liver metastases have been detected, the median survival time is in the range of 9–12 months [1–4], the extent of the tumor being the most important prognostic factor [4]. Local recurrence and liver metastases are the most common types of failure after “curative” colorectal surgery in clinical series [5].