Asymmetric Transformation Driven by Confinement and Self‐Release in Single‐Layered Porous Nanosheet

Asymmetric transformation requires the use of chiral catalysts which is hampered by energy intensive processes such as high cost, inefficient recycle, and tedious separation. Here we report the use of single-layered, chiral porous sheets with induced pore chirality for repeatable asymmetric transformation and self-separation without the need of chiral catalysts or chiral auxiliaries. The asymmetric induction is driven by chiral fixation of absorbed achiral substrates inside the chiral pores to transform into enantiopure products with enantioselectivity of greater than 99% ee . When the conversion is completed, the products are spontaneously separated out of the pores, enabling the porous sheets to perform repeated cycles of converting achiral substrates to release as chiral products without compromising pore performance, thereby confining achiral substrates into 2-D chiral porous materials provides access to a highly efficient alternative to current asymmetric synthesis methodologies.