Importance of hemodynamics management in patients with severe head injury and during hypothermia

Objective To evaluate the hemodynamics in patients with traumatic brain injury (TBI) during therapeutic hypothermia. Methods. Subjects were 25 patients with TBI (GCS; 8 or less). Mean arterial blood pressure (MAP), cerebral perfusion pressure (CPP), cardiac index (CI), systemic oxygen delivery (D02), systemic vascular resistance index (SVRI), and pulmonary capillary wedge pressure (PCWP) were measured. Patients were retrospectively divided into 3 groups: normothermia (n = 5; NT), and survivors (n = 14; HT-S) and non-survivors (n = 6; HT-Non-S) after hypothermia, and hemodynamics were investigated for difference among groups at 24 hours from induction of normothermia or hypothermia.