Research progress of the targeted therapy in severe asthma

Bronchial asthma(asthma) is a chronic airway inflammatory disease with obvious heterogeneity and complex pathophysiological manifestations. The prevalence of asthma in Chinese adults is 1.24%, of which severe asthma accounts for 5.99%. Severe asthma manifests as poor control which is the main cause of disability and death of asthma. Clinical treatment of severe asthma is tricky. In recent years, bio-targeted therapeutics targeting at the helper T cell (Th)2 and Th17 phenotypes have become one of the hot spots in the development of new asthma drugs. Bio-targeted therapeutics may be a new hope to patients with severe asthma. This review summarizes the research status of targeted therapy for severe asthma, hoping to provide reference for clinicians to treat severe asthma. Key words: Severe asthma; Targeted therapy