Apolipoprotein C-I Expression in the Brain in Alzheimer's Disease

Abstract The H2 allele of apolipoprotein (apo) C-I is associated with Alzheimer's disease (AD). However, this association is potentially confounded by the linkage disequilibrium of H2 with the ϵ2 and ϵ4 alleles of apoE and of H1 with the ϵ3 allele. To establish plausibility for a direct role for apoC-I in AD, we compared apoC-I and apoE protein and mRNA levels in postmortem specimens of frontal cortex and hippocampus from AD patients with levels in nondemented controls. In H2-allelic individuals (usually also ϵ4 carriers), apoC-I mRNA levels were strikingly lower with AD (by 65%, P P