Molecular scanning for mutations in the melanocortin-4 receptor gene in obese/diabetic Japanese
1999
Decreased function of the melanocortin-4 receptor (MC4R) was reported to cause late-onset obesity and insulin resistance in rodents. Thus mutations in the MC4R gene drew strong attention as a possible cause of obesity and diabetes. We screened for mutations in the MC4R gene in extremely obese [body mass index (BMI) ≥ 35 kg/m 2 ] Japanese with diabetes by direct sequencing. A heterozygous mutation (V103I) was detected in one case (2.0%), however the frequency was not significantly different from that in non-obese (BMI ≤ 24 kg/m 2 ) and non-diabetic subjects (2.7%). No other mutations were detected. These results suggest that mutations including V103I in the MC4R gene are not a major cause of obesity or diabetes in Japanese.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
39
Citations
NaN
KQI