Oncologic outcomes in 408 consecutive patient cohort treated with da Vinci robot-assisted radical prostatectomy.

Abstract The objective of this study is to evaluate the general characteristics and oncological results in a cohort of 408 cases submitted to da Vinci Standard 4-armed robot-assisted radical prostatectomy (RARP), performed between October 2006 and February 2015 at Clinico San Carlos hospital. Statistical analysis was performed with the SPSS 20.0 program. Qualitative variables are presented with their frequency distribution and quantitative variables with their mean and standard deviation or median and interquartile range. The χ2 test was used to analyze the association of qualitative variables. The disease-free survival outcome variable was evaluated with a Kaplan–Meier curve analysis, and the differences were contrasted with the Breslow test. A Cox regression model was adjusted. Among the results, we highlight the follow-up of 47 months (32–68.75 m), recurrence-free survival of 90 months (95% CI, 86–94), median time to recurrence of 23 months (10.5–37 m), recurrence 16.6% (68/408), biochemical recurrence (62/498, 15.2%) and 22% of complications, mostly Clavien I–II. The results are summarized in Tables 1–7 and Fig. 1. Conclusions (1) RARP is a safe technique with an acceptable percentage of complications, mostly minor (Clavien grades I and II), (2) We found a higher probability of remaining recurrence-free in the lower grades of the ISUP classification and a higher probability of recurrence in high-risk cases, and (3) The multivariate model showed that the ISUP grade was significantly related to survival and the ISUP and PSM classification grades were independent prognostic variables.