Relationship between nuclear DNA fragmentation, mitochondrial DNA damage and standard sperm parameters in spermatozoa of infertile patients with leukocytospermia.

Abstract The association of leukocytospermia with male fertility is still under debate. Our objective is to evaluate the impact of leukocytospermia on nuclear and mitochondrial DNA (mtDNA), on semen parameters as well as on biomarkers, which include oxidative stress and inflammatory cytokines, in Tunisian infertile men. The studied patients were divided into two groups: patients without leukocytospermia (Group 1) and patients with leukocytospermia (Group 2). DNA fragmentation evolved significantly in group 2 (31.41%) compared to group 1 (14.68%) ; (p