Additional file 1: Figure S1. of Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis

(A) Normalized band quantization data of pSTAT3 and SOCS3 in Fig. 1c by Image J between matched pancreatic cancer and pericancerous tissues were used to confirm our claim. (B) Normalized band quantization data of pSTAT3 and SOCS3 in Fig. 1d by Image J were evaluated. (C) The CCK8 assay was used to evaluate the proliferation of Panc1 cells after treatment with IL-6 (100 ng/ml) at 0 h, 24 h and 48 h. After seeding Bxpc3 cells for 24 h, we treated Bxpc3 cells with S31-201 (10IźM). The CCK8 assay was used to evaluate the proliferation of Bxpc3 cells after treatment with S31-201 at 0 h, 24 h and 48 h. (JPG 973 kb)