Quetotifen ophthalmic compositions stabilized and preserved
2006
An ophthalmic composition comprising: (a) quetotifen fumarate at a concentration of 0.01 to 0.1% (w / v) (b) a source of hydrogen peroxide that provides hydrogen peroxide in a trace amount of 0.001 to 0.01% (w / v); (c) one or more ocularly compatible hydrogen peroxide stabilizers selected from the group consisting of diethylene triamino penta (methylene phosphonic acid), 1-hydroxyethylidene-1,1-diphosphonic acid and physiologically compatible salts thereof, wherein the The composition is at a pH of 4 to 5.3 to stabilize the quetotifen salt against oxidation by hydrogen peroxide.
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