Packing effects on polymerization of diacetylene lipids in liposomes and monolayers matrices

Pore formation on the liposome resulted from the photo-cross-linking reaction between DC8,9PCs, which is a photo-polymerizable lipid, is only observed when the saturated lipids comprise of the hosting matrix. To understand the influence of the hosting matrix, the Langmuir monolayer is employed because the system is capable of precisely controlling the packing state and the compositions of the film. The kinetics of reaction is found to strongly depend on the packing state of the film, and the cross-distance between DC8,9PCs plays a key role for the polymerization reaction to proceed.