Combination Therapies for HPV-Associated Malignancies
2021
Human papillomavirus (HPV)-associated malignancies cause almost all cases of cervical cancer in women, and a
significant percentage of head and neck cancer, together totaling almost 5% of the global cancer burden, and
representing an important public health issue. The approval and use of two prophylactic HPV vaccines, Gardasil® and Cervarix®, have significantly decreased infections with HPV, but unfortunately, prophylactic vaccination does
not treat established infections or malignancies resulting from HPV. Therefore, therapies for HPV-associated
malignancies are necessary to improve the quality of life and survival in patients with these diseases. This review will
detail new combinations of therapies in clinical development for HPV-associated malignancies.
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