Preconditioning of mesenchymal stromal cells and its protection mechanism

Stem cell transplantation has opened up new worlds, with great prospects and hopes for clinical disease treatment, and it has made great progress. However, Bone mesenchyme stem cell therapy has been hindered by both key problems, lack of targetting/poor cell engraftment and apoptosis of the implanted cells, resulting in poor therapeutic effects thereby hampering extensive application of this technology in clinical. The stem cell pre-conditioning has brought new hope to solve these two problems. It has been proved that pretreatment of stem cells can improve its migration, homing and survival ability. To this end, the authours will review the related research. Key words: Stem cells; Transplantation; Preconditioning; Protection; Mechanism