Serum SYPL1 is a promising diagnostic biomarker for colorectal cancer

Abstract Background At present, the overall sensitivity and specificity of blood biomarkers are insufficient for a diagnosis of colorectal cancer (CRC). Methods We analyzed the serum synaptophysin like 1 (sSYPL1) in controls, adenoma patients, CRC patients, pre- and postoperative CRC patients by ELISA. Results The upregulation of SYPL1 was confirmed in CRC tissues at both mRNA and protein levels. Consistently, sSYPL1 was significantly higher in CRC patients than in either controls (t = 14.50, P  Conclusion sSYPL1 might be an outstanding marker for CRC diagnosis, especially for patients with low CEA levels.