Abstract 11329: Superiority of Assessing Endocardial Strain to Whole Wall Thickness Strain by Dobutamine Stress Echocardiography in the Dectection of Coronary Artery Disease

Background: Myocardial ischemia typically extends from the endocardium to the epicardium. Therefore methods of assessment myocardial functional abnormality at the endocardial layer may permit a more accurate detection of coronary artery disease (CAD) this was testified in the current study with the use of dobutamine stress echocardiography. Methods: After baseline echocardiographic scans obtained, 40 patients with suspected CAD underwent dobutamine stress echocardiography (peak dose, 40μg/kg/min). Coronary angiography was performed within 3 days after test. Echocardiographic images were post-processed by a layer-specific speckle tracking software (EchoPac Version 113, GE) to measure the peak longitudinal strain (STE-L) at the endocardium, midlayer, and epicardium as well as total wall thickness (STE-W). Results: Forty patients were enrolled into the study. Among them 22 (mean age of 56 ± 15 years) had significant coronary artery disease (stenosis >70%). This included single-vessel disease at left anterior...