Generalized Multinucleate Cell Angiohistiocytoma.

BackgroundThere are less than 100 cases of multinucleate cell angiohistiocytoma (MCA) currently reported in the literature. It occurs as a localized, asymptomatic, benign proliferation of the skin, characterized histologically by irregular multinucleate cells. Due to its novelty, the etiology of the disease and treatment options are still under investigation.ObjectiveTo report a case of confirmed, generalized MCA along with a review of the literature on the histology, immunology, potential etiology, and treatment of MCA.ObservationsThe patient was a 41-year-old female with asymptomatic violaceous plaques found on the extensor arms, legs, and trunk. Histopathology revealed increased dilated vascularity and cellularity (composed of mononuclear histiocytes and a few angulated multinucleated giant cells) in the dermis.ConclusionsOverall, MCA is a poorly understood, distinct dermatologic phenomenon. Here we present a case of generalized MCA to further the understanding of this disease presentation.