Effects of Total Flavonoids of Epimedium in Climacteric Model Rats

Objective: To investigate the effects of Total Flavonoids of Epimedium (TFE) in climacteric model rats. Method: Utilized castration method to make climacteric syndrome animal model and observed the effects of high middle and low doses of TFE(that is TFE-HD/TFE-MD/TFE-LD) on organ index, serum sex hormone, serum IL-2, BGP content in climacteric rats. Results: Compared with the blank group, the uterus index, spleen index and the level of serum E2, serum IL-2 and BGP levels of model group were significantly decreased (P<0.01), LH, FSH levels were significantly increased (P<0.01). Explained the incomplete removal of the ovaries rat model of climacteric appeared atrophy of spleen and uterus, sex hormone disordered and reduced the immunity and bone calcium.Compared with the model group, each treatment group could significantly increase the spleen index, TFE-MD could significantly improve the uterus index (P<0.05), TFE- HD could significantly improve the uterus index (P<0.01). The TFE in each dosage group and soybean isoflavones (SI) group could significantly increase the level of serum E2(P<0.01), TFE-HD and SI could significantly decrease the serum LH level, TFE-HD could significantly decrease the levels of FSH (P<0.01). Gengnian'an capsule group and TFE-HD were significantly increase serum IL-2 level; SI significantly increased serum BGP level, other each group could significantly increase the level of serum BGP. Conclusion: TFE had significant effect on the treatment of climacteric syndrome. KEYWORD: Total Flavonoids of Epimediu; Rats; Climacteric model