Cryochemical modification, activity, and toxicity of dioxidine

Dioxidine nanoparticles are prepared via cryochemical modification of the pharmacopoeial dioxidine substance. The form of the cryomodified dioxidine is characterized by data from 1H NMR spectroscopy; X-ray diffraction analysis; such thermal analytical methods as TG and DSC; low-temperature argon adsorption; and transmission electron microscopy. It is shown that the cryomodified samples are synthesized in the form of dioxidine nanocrystals 50–300 nm in size, with a crystal structure differing from that of the initial pharmacopoeial substance. The prepared cryomodified dioxidine nanoparticles inhibit the growth of E. coli 52, S. aureus 144, M. cyaneum 98, and B. cereus 9 better than the initial pharmacopoeial substance, and have comparable chronic toxicity.