Comparison Of Magnesium Sulfate And Normal Saline (Placebo) Nebulization For Prevention Of Postoperative Sore roat In Patients Undergoing Lumbar Spine Surgeries Under General Anaesthesia With Endotracheal Intubation In Prone Position

Background and Aims:Postoperative sore throat (POST) and hoarseness are common complaints after general anesthesia with tracheal intubation. Various nonpharmacological and pharmacological measures have been used to reduce POST with variable success. e present study was conducted to compare the efficiency of preoperative nebulization of normal saline and magnesium sulfate in reducing the incidence of POST following lumbar spinal surgeries under general anaesthesia with tracheal intubation in prone position. Materials and Methods: After ethical committee approval and written informed consent, a prospective randomized double-blinded study was conducted in 140 cases divided into two equal groups. Patients included in the study were of either gender belonging to American Society of Anesthesiologist (ASA) status 1 or 2 undergoing lumbar spine surgery requiring tracheal intubation in prone position. Patients in Group A are nebulized with 5 ml of normal saline and the patients in Group B are nebulized with 5 ml of 225 mg isotonic nebulized magnesium sulfate for 15 min, 5 min before induction of anesthesia. e incidence of POST at rest and any undue complaints at 1, 6, and 24 hrs in the postoperative period were evaluated. Results: e overall incidence of POST was 53%. 54(77%) patients in Group A and 21(30%) patients in Group B Experienced POST. Patients who experienced POST were compared for its severity. POST was significantly attenuated at 6hr in Group B compared to Group A. 4 Conclusions:MgSO significantly reduces the incidence of POST compared to normal saline.