Dramatic decline in new HIV diagnoses in persons born in France in a large nationwide HIV cohort.

Abstract Objectives As trends in new HIV diagnoses represent a measure of the HIV epidemic, we conducted a 6-year longitudinal study to evaluate the change in rates of new HIV diagnosis, stratified by birthplace, HIV risk groups and CD4 cell count at diagnosis in a large French multicentre cohort. Study design We performed a retrospective cohort study using data from the mainland French Dat’AIDS cohort. Methods Data were obtained for subjects with a new HIV diagnosis date between 2013 and 2018. HIV diagnosis date was defined as the date of the first known positive HIV serology. Results Between 2013 and 2018, a total of 68,376 people living with HIV (PLHIV) were followed in the Dat’AIDS cohort; 9543 persons were newly diagnosed with HIV. The annual number of new HIV diagnoses decreased from 1856 in 2013, to 1149 in 2018 (−38.1%), P = 0.01; it was more pronounced among subjects born in France, from 858 to 484 (−43.6%), P  Conclusion Our findings show changes in HIV epidemiology in PLHIV born in France, with a decline around 40% in new HIV diagnoses, and a more pronounced decrease among MSM and heterosexual women. Our results support the long-term effectiveness of the antiretroviral therapy as a prevention strategy among the various tools for HIV prevention.