Crohnâs Colitis with Marked Peripheral Eosinophilia

Crohn’s disease (CD) is a disorder of multifactorial etiology characterized by trans-mural inflammation of the gastrointestinal tract. CD may involve the entire gastrointestinal tract and causes extra-intestinal manifestations. Eosinophils are granulocytic leukocytes that play a key role in mucosal innate host defense and play role in the pathogenesis chronic inflammatory mucosal disorders, including inflammatory bowel disease (IBD) We are reporting a case of Crohn’s disease associated with marked peripheral eosinophilia. A 25-year old, asymptomatic male patient referred from hematology clinic to our gastroenterology clinic, in the European Gaza Hospital, for diagnostic work-up for his marked peripheral eosinophilia. Extensive Hematologic workup revealed no cause for his eosinophilia. During follow up, he reported having bouts of intermittent abdominal pain and diarrhea. Colonoscopy was carried out which showed the right colon showing inflamed mucosa along with deep linear ulcerations. Histopathology showed a picture consistent with Crohn’s disease. We would like to highlight the possible relationship between eosinophilia and Crohn’s disease. Taking that point in consideration during eosinophilia work up leads to earlier diagnosis and prevent unnecessary invasive and expensive diagnostic procedures.