Temporal Variation in Murine Kidney Toxicity to the Antituberculosis Agent (Isoniazid)
2018
Background: Isoniazid is a drug largely used for both the
treatment and prophylaxis of Tuberculosis. In this study, we
investigated whether INH-induced nephrotoxicity is
influenced by dosing-time.
Materials and Methods: A potentially toxic INH dose (120
mg/kg) was injected by i.p. route to different groups of
animals at three different circadian times: 1, 9 and 17 hours
after light onset (HALO). INH administration at 1 and 9 HALO
resulted in maximum and minimum nephrotoxicity
respectively. Toxicity was assessed by the significant
increase in both biochemical parameters of kidney function
(Urea: URE, Uric Acid: URI and Creatinine: CERT) and stress
oxidative (Malondialdehyde: MDA). These results were
correlated with the severe and minor renal
histopathological observed at 1 and at 9 HALO respectively.
Conclusion: The optimal tolerance or least side effects were
detected when INH was injected in the second part of the
light-rest span (9 HALO) of mice.
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