Radiosensitization in Cancer Treatment with Gold nanoparticles through Synergistic Sonoporation

We demonstrated synergistic radiosensitization in human liver cancer using gold nanoparticle-encapsulated microbubbles (AuMB) and ultrasound. Microbubbles-mediated sonoporation enhanced cellular uptake of gold nanoparticles (AuNP). Higher cavitation signals were associated with more DNA damages and inferior cancer cell survivals after mega-voltage (MV) X-ray irradiation.