Cerebrospinal fluid penetration of tigecycline.

AbstractWe report, in a clinical setting, the tigecycline concentration and area under the concentration–time curve (AUC) – both in blood and in cerebrospinal fluid (CSF) – of a patient with a ventriculo-atrial shunt infection. Tigecycline weakly penetrates CSF the CSF-to-serum concentration ratio was 0.079 and CSF-to-serum AUC0–12 ratio was 0.067.