AB0080 Treatment failure pulmonary haemorrhage of sistemic lupus

Background Objectives To describe the treatment and outcome of patients with SLE and pulmonary haemorrhage. Methods Retrospective study (1989–2000). Centre: Universitary Hospital. Area: 700,000 inhabitans. SLE clinic: 154 SLE patients were reviewed. All patients fulfilled the ACR criteria for SLE. Results All patients received plasmapheresis, 3 bolus of cyclophosphamide 12 mg/kg/day and prednisone 2 mg/kg/day iv. Mechanical ventilation was employed in all patients. Death was secondary to nosocomial infections. Conclusion Pulmonary haemorrhage is a rare and often fatal complication of SLE. There are no uniform recommendations for treatment. Mechanical ventilation and inmunosupresors were a risk factor for a increase mortality.