Cerebellar sub-structures in cognitive impairment: volumetric and microstructural analyses at different stages of multiple sclerosis

Recent studies have demonstrated the impact of cerebellar lesion load and atrophy on cognitive impairment in multiple sclerosis (MS) that might result from functional disconnection in the fronto-cerebellar loop and local modulation. However, structural alterations in posterior lobules, in which cognitive functioning seems preponderant, are still unknown.