EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemia

The ecotropic viral integration site-1 gene ( EVI1 ) encodes a zinc finger protein that functions as a transcriptional regulator of hematopoietic stem cell self-renewal and long-term multilineage repopulating activity.[1][1],[2][2] The mixed lineage leukemia gene (MLL ) rearrangements [i.e. t(11q23